This FAQ delves into the promising trends and developments in dyslipidaemia research. DOWNLOAD THE FULL REPORT HERE


Dyslipidaemia, a condition marked by abnormal blood lipid levels, poses a significant global health challenge, notably contributing to the risk of ischemic heart disease. With a surge in its prevalence over the last three decades, understanding the regional variations and advancements in research and treatment is crucial. 

What is dyslipidaemia, and how has its prevalence varied across different regions globally?

Dyslipidaemia refers to a condition characterized by abnormal blood lipid levels, which significantly increase the risk of ischemic heart disease. Over the last three decades, its prevalence has notably differed across various regions. Europe and America have exhibited higher rates of hypercholesterolemia compared to Southeast Asia and Africa. Specific countries in the Asia Pacific, such as Japan, Malaysia, and the Philippines, have showcased distinct variations in total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels, emphasizing the need for tailored interventions to address lipid-related health concerns effectively. Notably, China and India stand out as the topmost Asian locations with the highest burden of dyslipidaemia, contributing significantly to the global prevalence.

What are the primary approaches to treating dyslipidaemia, and how have recent guidelines emphasized specific targets for intervention?

Lifestyle modification, including dietary changes emphasizing vegetables, fruits, and whole grains, alongside regular aerobic exercise, constitutes the initial approach for treating dyslipidaemia. Statins, inhibiting 3-hydroxy-3methylglutaryl-coenzyme A (HMG-CoA) reductase, are commonly used as the first-line therapy. Recent updates in dyslipidaemia guidelines by prominent organizations like ESC, AHA/ACC/Multisociety, and CCS have prioritized LDL-C as the primary target for intervention, advocating intensified lipid-lowering treatment for high-risk individuals. Shared decision-making plays a central role in these guidelines, although some variations exist in risk estimation systems and treatment recommendations. Additionally, comprehensive strategies, particularly in patients with kidney disease, are recommended based on the severity of the condition.

How have dyslipidaemia clinical trials evolved globally since 2018, and which regions have shown significant progress in research and funding?

Since 2018, the global dyslipidaemia clinical trial landscape has witnessed significant advancements, with the Asia-Pacific region leading the way by conducting over 65% of the trials, primarily driven by Mainland China and South Korea. Notably, North America and Europe have collectively conducted nearly 30% of the trials, with hypertriglyceridemia accounting for a substantial focus. The clinical trial landscape indicated a balanced distribution of Phase 3 trials across the Asia-Pacific, Europe, and North America, influenced by factors such as patient demographics and regulatory frameworks. Europe displayed notable growth trends, exhibiting a compound annual growth rate (CAGR) of over 10% from 2018 to 2022, suggesting significant progress and a favorable research environment. In terms of venture capital funding, the United States, the Netherlands, and China attracted substantial investment, highlighting their robust positions in dyslipidaemia research and development. The contributions of prominent key opinion leaders from various countries have significantly advanced research and clinical trials in the field of dyslipidaemia.

How has the research landscape changed in recent years?

The landscape of dyslipidaemia research has witnessed significant progress globally, with distinct regional variations in prevalence, treatment approaches, and clinical trial dynamics. The increasing focus on tailored interventions, alongside the advancements in therapeutic strategies, reflects a concerted effort to address the challenges posed by dyslipidaemia. As key opinion leaders continue to play a pivotal role in driving research and development in this field, their contributions serve as a testament to the collective endeavor to mitigate the global burden of dyslipidaemia and related cardiovascular risks.